We provide an expert target safety assessment service, where we assess potential toxicity and safety concerns associated with your targets, aiding you in drug discovery and development. We provide review of target biology, function and biomolecular interaction networks. We identify potential target toxicities, overview of the effects of target deletion or over-expression, describe the target’s role in disease and present pre-clinical and clinical target modulators safety findings.
We heavily rely on manual curation when it comes to biology of target family, target function and involvement in human and animal diseases. We use several publicly available databases as well as our proprietary SysWiz database to extract mRNA and protein expression profiles, related proteins and intra- and inter- species variation.
We delivered TSA reports for targets from three quarters of all druggable families.